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Symbol Name ID |
Dll4
delta like canonical Notch ligand 4 MGI:1859388 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Leukopenia |
Splenomegaly |
Hypersplenism |
| Disease(s) Associated with DLL4 | |||
| Adams-Oliver syndrome |
| Mouse Phenotypes | immune system phenotype |
abnormal thymus cell ratio |
thymus hypoplasia |
decreased thymocyte number |
abnormal lymphopoiesis |
increased immature B cell number |
abnormal T cell differentiation |
decreased double-positive T cell number |
decreased CD4-positive, alpha-beta T cell number |
absent CD4-positive, alpha-beta T cells |
decreased CD8-positive, alpha-beta T cell number |
absent CD8-positive, alpha-beta T cells |
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| Availability | Mouse Genotype | ||||||||||||
| Dll4tm1Frad/Dll4tm1Frad Tg(Mx1-cre)1Cgn/0 (conditional) |
* | ||||||||||||
| Dll4tm1Frad/Dll4tm1Frad Foxn1tm3(cre)Nrm/Foxn1+ (conditional) |
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| Dll4tm1Kaho/Dll4tm1Kaho Tg(Foxn1-cre)8Ghr/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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